Inhibition of Angiogenesis

▼Inhibition of Angiogenesis

Angiogenesis means formation of new blood vessels from existing blood vessels. When we’re injured, angiogenesis occurs to heal the wound. However, angiogenesis is also occurring in the process of growth of cancer cells. Cancer cells try to form blood vessels to obtain oxygen and nutrients they need to grow. If angiogenesis is inhibited, cancer cells cannot form new vessels and thus cannot grow. Also, it has been shown that cancer cells metastasize by utilizing new blood cells. In other words, inhibiting angiogenesis prevents metastasis of cancer cells.

▼Verification of Angiogenesis-inhibiting Effect

We verified the angiogenesis-inhibiting function of mozuku-derived fucoidan and mekabu-derived fucoidan using Human Umbilical Vein Endothelial Cells (HUVECs).

・Method of experiment
Samples of mozuku-derived fucoidan and mekabu-derived fucoidan prepared to different concentrations were added to Human Umbilical Vein Endothelial Cells (HUVECs) and the cells were cultured. As a control, HUVECs to which Phosphate Buffered Saline (PBS) was added were also cultured.

Effects of Various Types of Fucoidan on Angiogenesis Inhibition
Both mozuku-derived fucoidan and mekabu-derived fucoidan inhibited Angiogenesis to different degrees according to their concentration. Also, the Angiogenesis-inhibiting effect of mekabu-derived fucoidan was greater than that of mozuku-derived fucoidan.

Mitigation action of fucoidan on anticancer drug treatment side effects

Today, active research is conducted on fucoidan and various bioactive functions of fucoidan, such as “anti-cancer action,” “cholesterol-lowering action,” “blood-pressure lowering action” and “anti-virus action,” have been revealed.

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